NON-SMALL CELL LUNG CANCER (NSCLC), EGFR DOWNSTREAM PATHWAY ACTIVATION AND TKI TARGETED THERAPIES SENSITIVITY: EFFECT OF THE PLASMA MEMBRANE-ASSOCIATED NEU3.

Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease.Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib).Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR.In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activatio

OBJECTIVE: The purpose of this study was to analyze the factors that influence of the time between birth and the beginning of breastfeeding, especially at the moment of the rapid HIV test results at hospital admission for delivery.METHODS: Cohort study of 932 pregnant women who underwent rapid HIV test admitted in the hospital for delivery in Baby-

Managers use the flexibility of current financial reporting standards to separate or aggregate items of income statement.This feature of the standards has led to separate or aggregate of items in the financial Whips-Quirts statements as one of the challenging issues for managers.Hence, the purpose of this research is to investigate thebehavior of m

Among the causes that influence cow welfare, heat stress induced by microclimatic conditions is one of the most relevant and many studies have investigated the efficacy of different cooling systems on animal health status.Nevertheless, the direct influence of the cooling systems on possible modifications of Power Scooters dairy cow behaviour has be